Macular and peripapillary retinal nerve fibre layer thickness in adults with amblyopia

作者：Walker Randy A^*; Rubab Shehla; Voll Alexandra R L; Erraguntla Vasudha; Murphy Paul H

来源：Canadian Journal of Ophthalmology, 2011, 46(5): 425-427.

DOI：10.1016/j.jcjo.2011.07.013

Objective: To evaluate macular and peripapillary retinal nerve fiber layer (RNFL) thickness in amblyopic eyes compared to the fellow eye.
Design: Cross-sectional study.
Participants: 30 patients (60 eyes) older than 18 years of age with amblyopia.
Methods: Inclusion criteria included individuals older than 18 years, amblyopia, and best-corrected visual acuity (BCVA) <= 20/40. A complete medical history was taken and an eye examination carried out. Optical coherence tomography (OCT) was carried out on both eyes of all patients. Exclusion criteria included intraocular pressure (IOP) > 23 mm Hg and eye pathology that may affect OCT measurements. The primary outcome measures were foveal thickness and average peripapillary RNFL thickness, which were compared using a paired t test. Quadrants in peripapillary scans and concentric rings in macular scans were analyzed.
Results: The average age was 56 years (range = 33-82 years). Visual acuity ranged from 20/40 to 20/4000 (mean = 20/275). The average peripapillary RNFL thickness was 90.6 mu m (SD = 9.6 mu m) in the amblyopic eye and 90.1 mu m (SD = 12.1 mu m) in the fellow eye (p = 0.64). The average macular thickness in amblyopic eyes was 260.1 mu m (SD = 32.0 mu m), and 254.7 mu m (SD = 32.5 mu m) in fellow eyes (p = 0.10). No statistical difference existed between peripapillary quadrants or macular concentric rings. These differences were smaller when the strabismic amblyopes were isolated.
Conclusions: There does not seem to be a difference in peripapillary RNFL or macular thickness between the amblyopic eye and fellow eye.

• 出版日期2011-10