Toll-like receptors and their role in host resistance to Toxoplasma gondii

作者：Yarovinsky Felix^*

来源：Immunology Letters, 2008, 119(1-2): 17-21.

DOI：10.1016/j.imlet.2008.05.007

• Toxoplasma gondii
• Toll-like receptors
• TLR11
• TLR2, MyD88
• IL-12
• IFN-gamma
• dendritic cells

Toxoplasma gondii and other apicomplexan parasites are widely distributed obligate intracellular protozoa. A critical host mediator produced in response to T gondii infection is IL-12. This cytokine is synthesized by dendritic cells, macrophages and neutrophils and plays a pivotal role in the production of IFN-gamma, which in turn activates anti-microbial effector cells. in the past several years, many of the receptors and signaling pathways that link pathogen detection to induction of IL-12 have been identified and characterized. Among these receptors the Toll-like receptor (TLR) family can recognize all classes of pathogens and induce different types of immune responses. In the following review, I summarize the evidence for specific TLR function in host resistance to T. gondii.

• 出版日期2008-8-15