Downregulation of miR-145-5p correlates with poor prognosis in gastric cancer

作者：Zhang, Y.; Wen, X.; Hu, X. -L.; Cheng, L. -Z.; Yu, J. -Y.; Wei, Z. -B.^*

来源：European Review for Medical and Pharmacological Sciences, 2016, 20(14): 3026-3030.

• miR-145-5p
• Gastric cancer (GC)
• Prognostic biomarker

OBJECTIVE: The aim of this study was to explore the clinical significance of miR-145-5p expression in gastric cancer (GC). @@@ PATIENTS AND METHODS: Expression of miR-145-5p was evaluated by qRT-PCR in tumor and normal gastric tissues in 145 GC patients. The correlation between the miR-145-5p expression and clinicopathological parameters was investigated. Finally, the survival was assessed by the Kaplan-Meier method and proportional hazards model. @@@ RESULTS: Expression levels of miR-145-5p in GC tissues were significantly lower than those in adjacent normal tissues (p < 0.001). MiR-1455p expression was significantly associated with lymph node metastasis, metastasis stage, and distant metastasis (all p < 0.05). Furthermore, patients with low miR-145-5p expression had poorer overall survival time than those with high miR-145-5p expression (p = 0.014). Moreover, univariate and multivariate Cox analysis showed that miR-145-5p was an independent prognostic indicator for OS (p = 0.011). @@@ CONCLUSIONS: MiR-145-5p is down-expressed in GC, and can be used as a marker of poor prognosis in GC patients.

• 出版日期2016-7
• 单位长治医学院