Antiretroviral Adherence and Development of Drug Resistance Are the Strongest Predictors of Genital HIV-1 Shedding among Women Initiating Treatment

作者：Graham Susan M^*; Masese Linnet; Gitau Ruth; Jalalian Lechak Zahra; Richardson Barbra A; Peshu Norbert; Mandaliya Kishor; Kiarie James N; Jaoko Walter; Ndinya Achola Jeckoniah; Overbaugh Julie; McClelland R Scott

来源：Journal of Infectious Diseases, 2010, 202(10): 1538-1542.

DOI：10.1086/656790

Persistent genital human immunodeficiency virus type 1 (HIV-1) shedding among women receiving antiretroviral therapy (ART) may present a transmission risk. We investigated the associations between genital HIV-1 suppression after ART initiation and adherence, resistance, pretreatment CD4 cell count, and hormonal contraceptive use. First-line ART was initiated in 102 women. Plasma and genital HIV-1 RNA levels were measured at months 0, 3, and 6. Adherence was a strong and consistent predictor of genital HIV-1 suppression (P < .001), whereas genotypic resistance was associated with higher vaginal HIV-1 RNA level at month 6 (Pp. 04). These results emphasize the importance of adherence to optimize the potential benefits of ART for reducing HIV-1 transmission risk.

• 出版日期2010-11-15