Additional Diagnostic Yield of Adding Serology to PCR in Diagnosing Viral Acute Respiratory Infections in Kenyan Patients 5 Years of Age and Older

作者：Feikin Daniel R; Njenga M Kariuki; Bigogo Godfrey; Aura Barrack; Gikunju Stella; Balish Amanda; Katz Mark A; Erdman Dean; Breiman Robert F

来源：Clinical and Vaccine Immunology, 2013, 20(1): 113-114.

DOI：10.1128/CVI.00325-12

The role of serology in the setting of PCR-based diagnosis of acute respiratory infections (ARIs) is unclear. We found that acute- and convalescent-phase paired-sample serologic testing increased the diagnostic yield of naso/oropharyngeal swabs for influenza virus, respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, and parainfluenza viruses beyond PCR by 0.4% to 10.7%. Although still limited for clinical use, serology, along with PCR, can maximize etiologic diagnosis in epidemiologic studies.

• 出版日期2013-1