Antioxidant and Anti-inflammatory Phenylpropanoid Derivatives from Calamus quiquesetinervius

作者：Chang Chao Lin; Zhang Li Jie; Chen Ru Yin; Kuo Li Ming Yang; Huang Jhih Ping; Huang Hui Chi; Lee Kuo Hsiung; Wu Yang Chang; Kuo Yao Haur^*

来源：Journal of Natural Products, 2010, 73(9): 1482-1488.

DOI：10.1021/np100181c

Eight new phenylpropanoid derivatives [quiquesetinerviusides A (1), B (2), C (3), D (4), and E (5), as well as quiquesetinerviusins A (6), B (7), and C (8)] and seven known compounds (8-15), were isolated from an EtOAc extract of Calamus quiquesetinervius stems. The structures of 1-8 were elucidated on the basis of 1D- and 2D-NMR spectroscopic data analysis. Bioassay results showed that 1-5 possess weak DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity, but potent (center dot)OH radical scavenging activity (IC(50) 3.6-8.4 mu M). Of the tested isolates, compounds 4-6 and 9 showed potent inhibition (IC(50) 9.2-29.5 mu M) of LPS-stimulated NO production when compared with a positive control substance, quercetin (IC(50) 34.5 mu M).

• 出版日期2010-9
• 单位中国医科大学