科研之友
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摘要
A stereoselective synthesis of L-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantloselective alpha-amlnation reaction of an acyclic beta-ketoester with di-tert-butyl azodicarboxylate induced by europium and (R,R)-dlphenyl-pybox.
- 出版日期2013-4-5
