Probing the reaction mechanism of aristolochene synthase with 12,13-difluorofarnesyl diphosphate

作者:Yu Fanglei; Miller David J; Allemann Rudolf K*
来源:Chemical communications, 2007, (40): 4155-4157.
DOI:10.1039/b709562g

摘要

12,13- Difluorofarnesyl diphosphate, prepared using Suzuki Miyaura chemistry, is a potent inhibitor of aristolochene synthase ( AS), indicating that the initial cyclisation during AS catalysis generates germacryl cation in a concerted reaction.

  • 出版日期2007