Untangling the role of tau in Alzheimer%26apos;s disease: A unifying hypothesis

作者：Bhatia Neha^*; Hall Garth F

来源：Translational Neuroscience, 2013, 4(2): 115-133.

DOI：10.2478/s13380-013-0114-5

• Tauopathy
• Secretion
• Alzheimer%26apos
• s disease pathogenesis
• Tau lesion spread
• Neurodegeneration
• Tauopathy models
• Tauopathy hypothesis

Recent investigations into the etiology and pathogenesis of Alzheimer%26apos;s disease (AD) in the past few years have expanded to include previously unexplored and/or disconnected aspects of AD and related conditions at both the cellular and systemic levels of organization. These include how AD-associated abnormalities affect the cell cycle and neuronal differentiation state and how they recruit signal transduction, membrane trafficking and protein transcytosis mechanisms to produce a neurotoxic syndrome capable of spreading itself throughout the brain. The recent expansion of AD research into intercellular and new aspects of cellular degenerative mechanisms is causing a systemic re-evaluation of AD pathogenesis, including the roles played by well-studied elements, such as the generation of A beta and tau protein aggregates. It is also changing our view of neurodegenerative diseases as a whole. Here we propose a conceptual framework to account for some of the emerging aspects of the role of tau in AD pathogenesis.

• 出版日期2013-6