Antioxidant and Acetylcholinesterase Inhibition Activity of Mulberry Fruit Extracts

作者：Lee Young Ju; Lee Ka Hwa; Ahn Chang Bum; Chun Soon Sil; Je Jae Young^*

来源：Food Science and Biotechnology, 2009, 18(6): 1532-1536.

• mulberry fruit
• antioxidant
• free radical
• lipid peroxidation
• acetylcholinesterase (AChE)

The objective of this study was to evaluate the antioxidant effects and acetylcholinesterase (ACNE) inhibition activity of mulberry fruit extracts prepared by hot water (MFH) and 80% ethanol (MFE). Total polyphenolic contents of MFH and MFE were 195 +/- 3.4 mg gallic acid equivalents/g MFH and 185 +/- 2.8 mg gallic acid equivalents/g MFE. MFH and MFE significantly quenched 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide dose-dependently, and showed high chelating ability and reducing power in non-cellular systems. MFH and MFE also inhibited the formation of intracellular reactive oxygen species and lipid peroxidation, and elevated intracellular glutathione (GSH) levels in RAW264.7 cells. In addition, MFH and MFE also dose-dependently suppressed AChE activity.

• 出版日期2009-12