Molecular light switches for calf thymus DNA based on three Ru(II) bipyridyl complexes with variations of heteroatoms

作者：Han Mei Jiao; Duan Zhi Ming; Hao Qiang; Zheng Shuai Zhi; Wang Ke Zhi^*

来源：Journal of Physical Chemistry C, 2007, 111(44): 16577-16585.

DOI：10.1021/jp075194k

The three Ru(II) complexes of [Ru(bpy)(2)(bipp)(ClO4)(2) (1), [Ru(bpy)(2)(bopp)](ClO4)(2) (2), and [Ru(bpy)(2)(btpp)](ClO4)(2) (3) (where bpy = 2,2 '-bipyridine, bipp = 2-benzimidazoyl-pyrazino[2,3-f] [1,10]phenanthroline, bopp = 2-benzoxazolyl-pyrazino[2,3-f] [1,10]phenanthroline, and btpp = 2-benzthiazolyl-pyrazino[2,3-f] [1,10]phenanthroline) with variations in heteroatoms of NH (1), O(2), and S(3), have been synthesized and characterized. These complexes have been shown to act as promising calf thymus DNA intercalators and a new class of DNA light switches for the DNA, as evidenced by UV - visible and luminescence titrations, steady-state emission quenching by [Fe(CN)61 '(4-), DNA competitive binding with ethidium bromide, reverse salt titrations, viscosity measurements, and DNA melting experiments.

• 出版日期2007-11-8
• 单位北京师范大学