A new diketopiperazine alkaloid isolated from an algicolous Aspergillus flavus strain

作者:Lin Aiqun; Fang Yuchun; Zhu Tianjiao; Gu Qianqun*; Zhu Weiming
来源:Pharmazie, 2008, 63(4): 323-325.
DOI:10.1691/ph.2008.7700

摘要

A new diketopiperazine alkaloid containing the uncommon amino acid L-7, 9-dihydroxy-8-methoxyphenylalanine (1), has been isolated from the algicolous Aspergillus flavus strain. The structure of 1 including the absolute stereochemistry was determined by spectroscopic data and chemical means. Compound 1 showed weak cytotoxicity against HL-60 cell lines with an IC50 value of 36.5 mu g/ml.