Mitochondrial dysfunction and Alzheimer's disease

作者：Maruszak Aleksandra^*; Zekanowski Cezary

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2011, 35(2): 320-330.

DOI：10.1016/j.pnpbp.2010.07.004

• Alzheimer's disease
• APOE4
• Mitochondrial DNA (mtDNA)
• Mitochondrial dysfunction
• Mitochondrial haplogroups
• Oxidative stress

To date, one of the most discussed hypotheses for Alzheimer's disease (AD) etiology implicates mitochondrial dysfunction and oxidative stress as one of the primary events in the course of AD. In this review we focus on the role of mitochondria and mitochondrial DNA (mtDNA) variation in AD and discuss the rationale for the involvement of mitochondrial abnormalities in AD pathology. We summarize the current data regarding the proteins involved in mitochondrial function and pathology observed in AD, and discuss the role of somatic mutations and mitochondrial haplogroups in AD development.

• 出版日期2011-3-30