Antibacterial substances from Albizia myriophylla wood against cariogenic Streptococcus mutans

作者：Joycharat Nantiya^*; Thammavong Sonesay; Limsuwan Surasak; Homlaead Sirilux; Voravuthikunchai Supayang Piyawan; Yingyongnarongkul Boon ek; Dej adisai Sukanya; Subhadhirasakul Sanan

来源：Archives of Pharmacal Research, 2013, 36(6): 723-730.

DOI：10.1007/s12272-013-0085-7

• Albizia myriophylla
• Leguminosae
• Lupinifolin
• Flavonoid
• Streptococcus mutans
• Medicinal plant

Albizia myriophylla has been used for long by Thai traditional healers as an important ingredient herb in Thai herbal formulas for caries. In this study, three flavonoids lupinifolin (6), 8-methoxy-7,3',4'-trihydroxyflavone (7), and 7,8,3',4'-tetrahydroxyflavone (8), a triterpenoid lupeol (3) as well as four sterols beta-sitosterone (1), stigmasta-5,22-dien-3-one (2), beta-sitosterol (4), and stigmasterol (5) were isolated from A. myriophylla wood. The antibacterial activity of these compounds against Streptococcus mutans ATCC 25175 was performed using broth microdilution method. All compounds exhibited antibacterial activity against S. mutans with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) ranging from 1-256 and 2-256 mu g/ml, respectively. Among the isolated compounds, lupinifolin (6) was found to be the most potent with MIC and MBC of 1 and 2 mu g/ml, respectively. Lupinifolin (6) also showed a strong activity against ten clinical isolates of S. mutans with MIC and MBC ranging from 0.25-2 and 0.5-8 mu g/ml, respectively. These results reported the bioactive ingredients of A. myriophylla which support its ethnomedical claims as well. Lupinifolin (6) may have a potential to be a natural anticariogenic agent.

• 出版日期2013-6