An Autopsy Case of Amyotrophic Lateral Sclerosis with Diaphragm Pacing

作者：Ito Hisashi^*; Kamei Tetsumasa; Odake Sanae; Nakano Masayuki; Okeda Riki; Kohriki Shunsaku; Kawachi Jun; Onders Raymond P; Yoshii Fumihito

来源：Internal Medicine, 2016, 55(23): 3511-3513.

DOI：10.2169/internalmedicine.55.7130

• amyotrophic lateral sclerosis
• respiratory insufficiency
• diaphragm pacing

Respiratory insufficiency is a critical problem in amyotrophic lateral sclerosis (ALS) patients. We herein present the case of an autopsied patient with sporadic ALS who underwent diaphragm pacing (DP). The pathology showed several localized adhesions with a markedly atrophied diaphragm. A marked loss of motor neurons with Bunina bodies and phosphorylated TDP-43 positive inclusions was found in the spinal cord and primary motor cortex. Mild hyalinization and a few multinucleated giant cells were present around the electrode tracks in the diaphragm. However, no infiltration of inflammatory cells was detected. Our findings suggest that full-time DP might not cause severe damage to adjacent diaphragm tissue.

• 出版日期2016