Neointimal fibrotic lead encapsulation - Clinical challenges and demands for implantable cardiac electronic devices

作者：Keiler Jonas; Schulze Marko; Sombetzki Martina; Heller Thomas; Tischer Tina; Grabow Niels; Wree Andreas; Baensch Dietmar

来源：Journal of Cardiology, 2017, 70(1-2): 7-17.

DOI：10.1016/j.jjcc.2017.01.011

• Lead failure
• Lead tissue encapsulation
• Vascular fibrosis
• Neointimal formation

Every tenth patient with a cardiac pacemaker or implantable cardioverter-defibrillator implanted is expected to have at least one lead problem in his lifetime. However, transvenous leads are often difficult to remove due to thrombotic obstruction or extensive neointimal fibrotic ingrowth. Despite its clinical significance, knowledge on lead-induced vascular fibrosis and neointimal lead encapsulation is sparse. Although leadless pacemakers are already available, their clinical operating range is limited. Therefore, lead/tissue interactions must be further improved in order to improve lead removals in particular. The published data on the coherences and issues related to lead associated vascular fibrosis and neointimal lead encapsulation are reviewed and discussed in this paper.

• 出版日期2017-8