Annexin A2 autoantibodies in thrombosis and autoimmune diseases

作者：Canas Felipe; Simonin Laurent; Couturaud Francis; Renaudineau Yves^*

来源：Thrombosis Research, 2015, 135(2): 226-230.

DOI：10.1016/j.thromres.2014.11.034

• Antiphospholipid syndrome
• Lupus
• Annexin A2
• Autoantibodies

Antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial, venous or small-vessel thrombotic events, and recurrent miscarriages or fetal loss. APS diagnosis is based on the repeated detection of anti-phospholipid (PL) antibodies (Ab), typically associated with anti-beta 2 glycoproteinI (beta 2GPI)-Ab. Recent studies suggest that anti-beta 2GPI Ab activity involves a protein complex including beta 2GPI and annexin A2 (ANXA2). Anti-ANXA2 Ab recognizes this complex, and these Ab can effectively promote thrombosis by inhibiting plasmin generation, and by activating endothelial cells. Therefore, anti-ANXA2 Ab represent a new biomarker, which can be detected in up to 25% of APS patients. Moreover, anti-ANXA2 Ab have been detected, in thrombotic associated diseases including pre-eclampsia, in other autoimmune diseases, and in cancer.

• 出版日期2015-2