A novel role for the transcription factor HIF-1 alpha in the formation of mast cell extracellular traps

作者：Branitzki Heinemann Katja; Okumura Cheryl Y; Voellger Lena; Kawakami Yuko; Kawakami Toshiaki; Naim Hassan Y; Nizet Victor^*; Von Koeckritz Blickwede Maren

来源：Biochemical Journal, 2012, 446(1): 159-163.

DOI：10.1042/BJ20120658

• AKB-4924
• echinomycin
• hypoxia-inducible factor-1 alpha (HIF-1 alpha)
• mast cell
• mast cell extracellular trap
• Staphylococcus aureus

MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1 alpha (hypoxia-inducible factor-1 alpha) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).

• 出版日期2012-8-15