Muscle wasting in cancer: the role of mitochondria

作者：Argiles Josep M^*; Lopez Soriano Francisco J; Busquets Silvia

来源：Current Opinion in Clinical Nutrition and Metabolic Care, 2015, 18(3): 221-225.

DOI：10.1097/MCO.0000000000000164

• brown adipose tissue
• cancer cachexia
• mitochondria
• muscle wasting
• phosphorylation

Purpose of reviewThe aim of the present review is to examine the impact of mitochondrial dysfunction in cancer cachexia.Recent findingsOxidative pathways are altered in this tissue during muscle wasting and this seems to be a consequence of mitochondrial abnormalities that include altered morphology and function, decreased ATP synthesis and uncoupling.SummaryAn alteration of energy balance is the immediate cause of cachexia. Both alterations in energy intake and expenditure are responsible for the wasting syndrome associated with different types of pathological conditions, such as cancer. Different types of molecular mechanisms contribute to energy expenditure and, therefore, involuntary body weight loss, one of which is mitochondrial dysfunction.

• 出版日期2015-5