Universal tumor-reactive helper peptides from telomerase as new tools for anticancer vaccination

作者：Dosset Magalie; Vauchy Charline; Beziaud Laurent; Adotevi Olivier; Godet Yann^*

来源：OncoImmunology, 2013, 2(3): e23430.

DOI：10.4161/onci.23430

• CD4 T cell
• cancer vaccine
• helper peptide
• immunotherapy
• telomerase

Accumulating evidence demonstrates the importance of CD4(+) T cells in antitumor immune responses. Identifying promiscuous MHC class II-binding peptides derived from relevant tumor-associated antigens that specifically target CD4(+) helper T cells in vivo represent a powerful approach to fully exploit these cells for anticancer immunotherapy.

• 出版日期2013-3-1