A slightly high-normal glucose level is associated with increased arterial stiffness in Japanese community-dwelling persons with pre-diabetes

作者：Kawamoto Ryuichi^*; Tabara Yasuharu; Kusunoki Tomo; Abe Masanori; Kohara Katsuhiko; Miki Tetsuro

来源：Vascular Medicine, 2013, 18(5): 251-256.

DOI：10.1177/1358863X13503192

• Arterial stiffness
• fasting plasma glucose
• pulse wave velocity
• risk factor

Impaired fasting glucose (IFG) in diabetes is a risk factor for arterial stiffness and cardiovascular disease (CVD), but the impact of a slightly high-normal glucose level remains controversial. We investigated whether slightly high-normal fasting plasma glucose (FPG) was independently associated with arterial stiffness in non-diabetic community-dwelling persons. We recruited 114 men aged 69 +/- 9 years (range 40-89) and 208 women aged 68 +/- 7 years (range 36-84) during their annual health examination in a single community. Arterial stiffness was evaluated by the mean of the right and left brachial-ankle pulse wave velocity (ba-PWV). Age-adjusted ba-PWV increased significantly from the lowest to the highest FPG group (p %26lt; 0.001). Multiple linear regression analyses for ba-PWV revealed that FPG levels (=0.154, p %26lt; 0.001) were independently and significantly associated with ba-PWV. The multivariate-adjusted ba-PWV value of the high-normal glucose group (Group 3: 95-100 mg/dL) was significantly higher than that of the lowest normal glucose group (Group 1: 52-89 mg/dL) (p=0.021), and the ba-PWV value in the IFG group (Group 4: 101-125 mg/dL) was significantly higher than those of the normal glucose groups (Group 1: %26lt;90 mg/dL; Group 2: 90-94 mg/dL) (p%26lt;0.001 and p=0.009, respectively). Slightly high-normal glucose levels were associated with arterial stiffness in Japanese community-dwelling persons.

• 出版日期2013-10