Aortic Valve Replacement in a Patient with Alpha-Thalassemia

作者：Omoto Tadashi^*; Tedoriya Takeo; Kondo Yasuyuki; Izuka Hirofumi; Oi Masaya; Nagano Naoko; Miyauchi Tadamasa; Ishikawa Noboru; Kasegawa Hitoshi

来源：Annals of Thoracic and Cardiovascular Surgery, 2010, 16(5): 365-366.

• anemia
• valve
• coagulation

Cardiac valve disease resulting from elastic tissue defects has been demonstrated in patients with beta-thalassemia; however, valve disorders of patients with alpha-thalassemia have been rarely discussed. We present the case of a patient with alpha-thalassemia and severe aortic regurgitation with left ventricular dysfunction. The patient underwent successful aortic valve replacement with mechanical prosthesis. Histopathology of the excised valve showed elastic tissue disruption and chronic thrombus on the ventricular side. Hypercoagulative states have been observed in patients with alpha-thalassemia as beta-thalassemia; therefore special attention should be taken in perioperative anticoagulation therapy. (Ann Thorac Cardiovasc Surg 2010; 16: 365-366)

• 出版日期2010-10