科研之友
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摘要
Host genetic factors may confer susceptibility to Cervical Cancer (CC). Tumor necrosis factor alpha (TNF-alpha) as proinflammatory cytokine participates in the maintenance of immune homeostasis. Allelic variation of immunomodulatory genes is associated with alteration in immune function. This study investigated the relationship between TNF-alpha-308G>A, -238G>A, and TNFRII-VNTR-322 and cervical cancer in Han China women. Genotypes of those polymorphisms were detected by restriction fragment length polymorphism polymerase Chain Reaction (RFLP-PCR) in 240 cases and 220 controls from the Huaihe Hospital affiliated to Henan University. The variant heterozygote-308 G/A was associated with a 39% decreased risk of cervical cancer (GG vs. A/A; P = 0.012; OR = 0.45; 95% CI = 0.21-0.78). Furthermore, compared with dominant variant G/G, the (G/A+A/A) genotypes was significantly associated with a decreased risk of CC (GG vs. G/A+A/A; P = 0.025; OR = 0.61; 95% CI = 0.42-0.96). The FIGO stratified analysis showed that the minor variant A/A and combined G/A+A/A of TNF-alpha-238 G>A and TNF-alpha-308 G>A increased the risk of the tumor evolution, respectively, (P = 0.011; OR = 2.91; 95% CI = 1.11-7.79) (P = 0.005; OR = 2.79; 95% CI = 1.28-6.81), (P = 0.001; OR = 15.33; 95% CI = (5.18-50.23) (P = 0.001; OR = 7.46; 95% CI = 2.61-20.29). There was statistically significant association between the TNF-alpha polymorphism and the clinical progression of cancer according to the FIGO classification. In this study, the haploview analysis revealed no LD between TNF-alpha-308G>A, -238G A. Variations in TNF-alpha might grant genetic risk factors for cervical cancer in China population. Study on partial genetic factors in CC patients plays crucial role in CC prevention, diagnosis and treatment.
- 出版日期2016
- 单位河南大学
