Emergence of OXA-48 and OXA-181 Carbapenemases among Enterobacteriaceae in South Africa and Evidence of In Vivo Selection of Colistin Resistance as a Consequence of Selective Decontamination of the Gastrointestinal Tract

作者：Brink Adrian J^*; Coetzee Jennifer; Corcoran Craig; Clay Cornelis G; Hari Makkan Danusha; Jacobson Rachael K; Richards Guy A; Feldman Charles; Nutt Louise; van Greune Johan; Deetlefs J D; Swart Karin; Devenish Lesley; Poirel Laurent; Nordmann Patrice

来源：Journal of Clinical Microbiology, 2013, 51(1): 369-372.

DOI：10.1128/JCM.02234-12

This study reports on the emergence of OXA-48-like carbapenemases among isolates of Enterobacteriaceae in South Africa. In addition, the emergence during therapy of a colistin-resistant OXA-181-producing Klebsiella pneumoniae isolate was documented following selective digestive tract decontamination with oral colistin, which is therefore strongly discouraged.

• 出版日期2013-1