Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels

作者：Pardo Alejandro Ciocci; Rinaldi Gustavo J; Mosca Susana M^*

来源：Mitochondrion, 2015, 20: 75-81.

DOI：10.1016/j.mito.2014.12.003

• Ca2+-retention capacity
• WKY
• SHR
• mPTP
• Delta Psi m
• Ca2+ response

The aim was to study the mitochondrial Ca2+ handling of mitochondria isolated from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) hearts and to establish a possible correlation with systolic blood pressure (SBP). Mitochondrial swelling after Ca2+ addition, Ca2+-retention capacity (CRC) by calcium green method, and membrane potential (Delta Psi m) were assessed. SBP was 124 +/- 1 (WKY) and 235 +/- 6 mm Hg (SHR). CRC, Ca2+ response and Delta Psi m were lower in SHR than WKY mitochondria. The conclusion is: the more depolarized state of SHR than WRY mitochondria results in an abnormal Ca2+ handling and this event is closely associated with the SBP.

• 出版日期2015-1