Age-associated decrease in serum glial cell line-derived neurotrophic factor levels in patients with major depressive disorder

作者：Tseng Ping Tao; Lee Yu; Lin Pao Yen^*

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2013, 40: 334-339.

DOI：10.1016/j.pnpbp.2012.09.009

• Glial cell line-derived neurotrophic factor (GDNF)
• Major depressive disorder
• Neurotrophic factor

Background: Many studies have supported the role of neurotrophic hypothesis in the pathophysiology of mood disorders. This study examined serum levels of glial cell line-derived neurotrophic factor (GDNF), one of the neurotrophic factors, in patients with major depressive disorder (MDD) at different disease states.
Methods: The serum GDNF levels were measured in 55 patients with MDD (29 severe patients and 26 remitted patients) and 35 healthy controls by ELISA method. Severity of depressive symptoms was assessed using the 17-item Hamilton Rating Scale of Depression (HAM-D) (HAM-D >= 19 for severe MDD, HAM-D <= 7 for remitted MDD).
Results: MDD patients were found to have significantly lower serum GDNF levels than healthy controls (p<0.001). This decrease was significant in older-aged (p = 0.003) and middle-aged (p = 0.026) groups, but not in the younger-aged group. We found no difference in GDNF level between severe and remitted MDD patients.
Conclusions: In spite of some limitations, our results indicate an age-associated reduction in serum GDNF leve

• 出版日期2013-1-10