Assessment of Tamsulosin as a Potential Male Contraceptive in Healthy Volunteers

作者：Wang, Jin; Zhao, Yong; Jiang, Shao-bo; Xia, Qing-hua; Wei, Chun-xiao; Wang, Mu-wen; Sun, Peng; Jin, Xun-bo^*

来源：Urology, 2012, 80(3): 614-617.

DOI：10.1016/j.urology.2012.06.003

• BENIGN PROSTATIC HYPERPLASIA
• SUBTYPE MESSENGER-RNAS
• DOUBLE-BLIND
• ALPHA-1-ADRENOCEPTOR ANTAGONISTS
• SELECTIVE ALPHA-1A-BLOCKER
• ALPHA-BLOCKERS
• ALFUZOSIN
• QUANTIFICATION
• EJACULATION
• SILODOSIN

OBJECTIVE To investigate the efficacy and safety of tamsulosin, an alpha(1A)-adrenoceptor antagonist, as a potential male contraceptive.
METHODS Forty healthy male volunteers were equally divided into 2 groups, each of which received placebo and tamsulosin sequentially in a crossover manner. Ejaculatory profile was examined 4 to 6 hours after administration and adverse effects were noted.
RESULTS Anejaculation occurred in all subjects after taking 0.8-mg of tamsulosin. Total functional sperm count was significantly reduced in subjects after taking 0.4-mg of tamsulosin. Six subjects receiving 0.8-mg of tamsulosin complained of tolerated discomfort, which disappeared 10 hours after administration.
CONCLUSION When administered at 0.8 mg, tamsulosin can cause anejaculation with some transient side effects. Our results imply that tamsulosin and related drugs might potentially be used as male contraceptive agents in the future, which needs more studies to verify. UROLOGY 80: 614-617, 2012.

• 出版日期2012-9
• 单位山东大学