α-adrenergic agonist brimonidine control of experimentally induced myopia in guinea pigs: A pilot study

作者：Liu, Yan; Wang, Yuexin; Lv, Huibin; Jiang, Xiaodan; Zhang, Mingzhou; Li, Xuemin^*

来源：Molecular Vision, 2017, 23.

• PIRENZEPINE OPHTHALMIC GEL
• UNDERLYING OCULAR GROWTH
• OPEN-ANGLE GLAUCOMA
• INTRAOCULAR-PRESSURE
• AXIAL LENGTH
• BIOMECHANICAL PROPERTIES
• REFRACTIVE ERROR
• PARALLEL SAFETY
• UNITED-STATES
• CHILDREN

Purpose: To investigate the efficacy of a-adrenergic agonist brimonidine either alone or combined with pirenzepine for inhibiting progressing myopia in guinea pig lens-myopia-induced models. @@@ Methods: Thirty-six guinea pigs were randomly divided into six groups: Group A received 2% pirenzepine, Group B received 0.2% brimonidine, Group C received 0.1% brimonidine, Group D received 2% pirenzepine + 0.2% brimonidine, Group E received 2% pirenzepine + 0.1% brimonidine, and Group F received the medium. Myopia was induced in the right eyes of all guinea pigs using polymethyl methacrylate (PMMA) lenses for 3 weeks. Eye drops were administered accordingly. Intraocular pressure was measured every day. Refractive error and axial length measurements were performed once a week. The enucleated eyeballs were removed for hematoxylin and eosin (H&E) and Van Gieson (VG) staining at the end of the study. @@@ Results: The lens-induced myopia model was established after 3 weeks. Treatment with 0.1% brimonidine alone and 0.2% brimonidine alone was capable of inhibiting progressing myopia, as shown by the better refractive error (p=0.024; p=0.006) and shorter axial length (p=0.005; p=0.0017). Treatment with 0.1% brimonidine and 0.2% brimonidine combined with 2% pirenzepine was also effective in suppressing progressing refractive error (p=0.016; p=0.0006) and axial length (p=0.017; p=0.0004). The thickness of the sclera was kept stable in all groups except group F; the sclera was much thinner in the lens-induced myopia eyes compared to the control eyes. @@@ Conclusions: Treatment with 0.1% brimonidine alone and 0.2% brimonidine alone, as well as combined with 2% pirenzepine, was effective in inhibiting progressing myopia. The result indicates that intraocular pressure elevation is possibly a promising mechanism and potential treatment for progressing myopia.

• 出版日期2017-11-15
• 单位北京大学