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摘要
A phytochemical study on the ethanolic extract of the stem barks of Uncaria laevigata leads to the isolation and characterization of 18 triterpenoid compounds. Ten of these are new, including one novel heptanortriterpenoid (1), four ursane titerpenes (2-4, 10), and five oleanane triterpenes (5-9). Their structures were established by spectroscopic methods, especially by 2D-NMR and MS analyses. All these isolates were evaluated for their inhibitory effects on alpha-glucosidase: ursolic acid and 3 showed potent activities with IC50 values of 16 +/- 2.2 and 49 +/- 3.7 mu M, respectively.
- 出版日期2013-10
- 单位中国药科大学; 天然药物活性组分与药效国家重点实验室
