科研之友
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摘要
Background: Diurnal temperature range (DTR) reflects within-day temperature variability and is closely associated with climate change. In comparison to temperature extremes, up-to-date DTR-health evidence at the regional and national scales has been still very limited worldwide, especially in Europe. Objectives: This study aimed to provide nationwide estimates for DTR-associated effects on mortality, and explore whether season and regional-level characteristics modify DTR-mortality relation in United Kingdom. Methods: Fourteen-year time-series data on weather and mortality were collected from 10 regions in England and Wales during 1993-2006, including 7,573,716 total deaths. A quasi-Poisson regression incorporated with distributed lag non-linear model was first applied to estimate region-specific DTR-mortality relationships. Then, a multivariate meta-analysis was employed to derive the pooled DTR effects at the national level. Also, the modifying effects of some regional characteristics (e.g., geographical and climatological) were examined by conducting multivariate meta-regression. Results: A non-linear DTR-mortality relationship was identified in UK. At the national level, increasing DTR raised the mortality risk observably when DTR exposure was below 25th percentile or above 90th percentile of DTR distribution, with an intermediate risk plateau indicating no associations. Extremely high DTR exhibited greater adverse effect estimates in hot season compared with in cold and transitional season, whereas entirely different association patterns were observed for the season-specific effects of extremely low DTR. In addition to season, regional latitudes, average temperature and humidity were also found to significantly modify DTR-mortality relationship. Conclusions: Our study added strong evidence that extremely high DTR increased short-term mortality, whereas the effects of extremely low DTR exhibited entirely different seasonal patterns. Also, mortality vulnerability to DTR extremes varied greatly by regional latitudes and climate conditions.
