Building Molecular Complexity via Tandem Ru-catalyzed Isomerization/C-H Activation

作者：Bartoszewicz Agnieszka; Martin Matute Belen^*

来源：Organic Letters, 2009, 11(8): 1749-1752.

DOI：10.1021/ol900243x

A tandem isomerization/C-H activation of allylic alcohols was performed using a catalytic amount of RUCl(2)(PPh(3))(3). A variety of ortho alkylated ketones have been obtained in excellent yields. This tandem process relies on an in situ generation of a carbonyl functional group that directs the ortho C-H bond activation.

• 出版日期2009-4-16