Adipose-Derived Mesenchymal Stem Cells Ameliorate Lipid Metabolic Disturbance in Mice

作者：Liu, Guang-Yang; Liu, Jin; Wang, You-Liang; Liu, Yang; Shao, Yong; Han, Yan; Qin, Ya-Ru; Xiao, Feng-Jun; Li, Peng-Fei; Zhao, Lan-Jun; Gu, En-Yan; Chen, Si-Yu; Gao, Li-Hua; Wu, Chu-Tse; Hu, Xian-Wen^*; Duan, Hai-Feng^*

来源：Stem Cells Translational Medicine, 2016, 5(9): 1162-1170.

DOI：10.5966/sctm.2015-0239

• Adipose-derived mesenchymal stem cell
• Anti-obesity
• Lipid metabolism
• Adenosine monophosphate-activated protein kinase

Adipose-derived mesenchymal stem cells (AD-MSCs) have been shown to ameliorate hyperglycemia in diabetic animals and individuals. However, little is known about whether AD-MSCs affect lipid metabolism. Here we have demonstrated for the first time that AD-MSC infusion can significantly suppress the increase in body weight and remarkably improve dyslipidemia in db/db obese mice and diet-induced obesity mice. Induction of white fat tissue "browning" and activation of adenosine monophosphate-activated protein kinase and its downstream hormone-sensitive lipase in adipose tissue contribute to the antiobesity and lipid-lowering effects. Thus, AD-MSC infusion holds great therapeutic potential for dyslipidemia and associated cardiovascular diseases.

• 出版日期2016-9
• 单位北京中医药大学; 中国人民解放军总医院