Application and Progress of Combined Mesenchymal Stem Cell Transplantation in the Treatment of Ischemic Cardiomyopathy

作者：Hua, Ping^*; Liu, Jian-Yang; Tao, Jun; Yang, Song-Ran

来源：Biomed Research International, 2015, 2015: 568502.

DOI：10.1155/2015/568502

• ACUTE MYOCARDIAL-INFARCTION
• LEFT-VENTRICULAR FUNCTION
• BONE-MARROW-CELLS
• REGENERATION ENHANCEMENT
• INHIBITED APOPTOSIS
• SERUM DEPRIVATION
• PROGENITOR CELLS
• CARDIAC-FUNCTION
• CONTROLLED-TRIAL
• HYPOXIA

Treatment of ischemic cardiomyopathy caused by myocardial infarction (MI) using mesenchymal stem cell (MSC) transplantation is a widely researched field, with promising clinical application. However, the low survival rate of transplanted cells has a severe impact on treatment outcome. Currently, research is focused on investigating the strategy of combining genetic engineering, tissue engineering materials, and drug/hypoxia preconditioning to improve ischemic cardiomyopathy treatment outcome using MSC transplantation treatment (MSCTT). This review discusses the application and progress of these techniques.

• 出版日期2015
• 单位中山大学