A highly sensitive colorimetric sensor for adrenaline detection based on organic molecules-functionalized gold nanoparticles

作者：Chen, Zhengbo^*; Hu, Yiming; Yang, Qinrui; Wan, Chongqing; Tan, Yuan; Ma, He

来源：Sensors and Actuators B: Chemical , 2015, 207: 277-280.

DOI：10.1016/j.snb.2014.10.067

• 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazol
• Colorimetric detection
• Gold nanoparticles
• Adrenaline

Herein a simple and rapid colorimetric adrenaline sensor based on 4-amino-3-hydrazino-5-mercapto-1,2,4-triazol (AHMT)-functionalized gold nanoparticles (AuNPs) was presented. This assay relied upon the distance-dependent optical properties of AuNPs, and the aggregation of AuNPs was induced by the strong hydrogen bonding between AHMT and adrenaline. The colorimetric sensor exhibited a high sensitivity with a low detection limit of 1 nM. Furthermore, we demonstrated the application of the present approach in human serum sample, which suggested its great potential for diagnostic purposes.

• 出版日期2015-2
• 单位首都师范大学