Angiotensin II Type 1 and Type 2 Receptor-induced Cell Signaling

作者：Akazawa Hiroshi; Yano Masamichi; Yabumoto Chizuru; Kudo Sakamoto Yoko; Komuro Issei^*

来源：Current Pharmaceutical Design, 2013, 19(17): 2988-2995.

• Angiotensin II
• mechanical stress
• receptor dimerization
• renin-angiotensin system
• signal transduction

The octapeptide angiotensin II (Ang II) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and also contributes to the progression of cardiovascular remodeling. Ang II activates Ang II type 1 (AT(1)) receptor and type 2 (AT(2)) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family. Most of the actions of Ang II such as promotion of cellular prolifaration, hypertrophy, and fibrosis are mediated by AT(1) receptor. However, in some pathological situations, AT(2) receptor shows an increase in tissue expression and functions to antagonize the actions induced by AT(1) receptor. Recent studies have advanced our understanding of the molecular mechanisms underlying receptor activation and signal transduction of AT(1) and AT(2) receptor in the cardiovascular system.

• 出版日期2013-5