Expression and Function of Tetraspanins and Their Interacting Partners in B Cells

作者：Zou, Fagui; Wang, Xu; Han, Xinxin; Rothschild, Gerson; Zheng, Song Guo; Basu, Uttiya^*; Sun, Jianbo^*

来源：Frontiers in Immunology, 2018, 9: 1606.

DOI：10.3389/fimmu.2018.01606

• tetraspanin
• B cell
• partner
• immune regulation
• therapy strategy

Tetraspanins are transmembrane proteins that modulate multiple diverse biological processes, including signal transduction, cell-cell communication, immunoregulation, tumorigenesis, cell adhesion, migration, and growth and differentiation. Here, we provide a systematic review of the involvement of tetraspanins and their partners in the regulation and function of B cells, including mechanisms associated with antigen presentation, antibody production, cytokine secretion, co-stimulator expression, and immuno suppression. Finally, we direct our focus to the signaling mechanisms, evolutionary conservation aspects, expression, and potential therapeutic strategies that could be based on tetraspanins and their interacting partners.

• 出版日期2018-7-18
• 单位中山大学