Amberlyst A21: A reusable solid catalyst for green synthesis of pyran annulated heterocycles at room temperature

作者：Bihani Manisha; Bora Pranjal P; Bez Ghanashyam^*; Askari Hassan

来源：Comptes Rendus Chimie, 2013, 16(5): 419-426.

DOI：10.1016/j.crci.2012.11.018

• Pyrans
• MCRs
• Amberlyst A21
• Green synthesis

Amberlyst A21, a neutral ion-exchange resin and a solid base, can catalyze the three-component reaction of aldehyde and malononitrile with various active methylene compounds at room temperature to synthesize a range of pharmaceutically important pyran annulated heterocycles. Use of the solid base could generate a highly green protocol by eliminating chromatographic purification that involves hazardous organic solvents, and facilitate easy recovery and reusability of the catalyst.

• 出版日期2013-5