New synthesis process for 2-(3-thienyl) malonic acid

作者：Feng R^*; Chen L; Zhang S; Song J

来源：Petrochemical Technology, 2008, 37(6): 592-596.

• 2-(3-thienyl) malonic acid
• 3-bromothiophene
• 3-iodothiophene
• Coordination catalysis
• Diethyl 2-(3-thienyl) malonate
• Iodination

2-(3-Thienyl) malonic acid was synthesized from 3-bromothiophene with coordinative catalyst, through a new route, namely iodination, condensation, hydrolysis and acidification. 3-Bromothiophene reacted with KI in n-butanol with CuI/N, N';-dimethylethane-1, 2-diamine as catalyst system. Yield of obtained 3-iodothiophene reaches 91.73. The 3-iodothiophene converted to diethyl 2-(3-thienyl) malonate by condensation with sodium salt of diethyl malonate in presence of CuBr as catalyst. Yield of obtained diethyl 2-(3-thienyl) malonate is 76.30 based on 3-iodothiophene. 2-(3-Thienyl) malonic acid was prepared by hydrolysis and acidification with a yield of 82.63. Total yield of 2-(3-thienyl) malonic acid by this route is 57. 83 based on 3-bromothiophene.

• 出版日期2008
• 单位天津大学