A beta-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus

作者：Inman Wayne D; Bray Walter M; Gassner Nadine C; Lokey R Scott; Tenney Karen; Shen Young Yongchun; TenDyke Karen; Suh Ted; Crews Phillip^*

来源：Journal of Natural Products, 2010, 73(2): 255-257.

DOI：10.1021/np9005426

A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid. named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure Was elucidated front spectroscopic data, including (1)H-(15)N HMBC NMR experiments, Which provided complementary (15)N chemical shift information ill support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.

• 出版日期2010-2