A phase 1 study of gemcitabine combined with dasatinib in patients with advanced solid tumors

作者：Hong David S^*; Choe Jennifer Hsing; Naing Aung; Wheler Jennifer J; Falchook Gerald S; Piha Paul Sarina; Moulder Stacy L; George Goldy C; Choe Jonathan M; Strauss Lewis C; Gallick Gary E; Kurzrock Razelle

来源：Investigational New Drugs, 2013, 31(4): 918-926.

DOI：10.1007/s10637-012-9898-3

• Dasatinib
• Gemcitabine
• Pancreatic cancer
• Phase 1
• Advanced solid tumors

Purpose Dasatinib has been shown preclinically to overcome resistance to gemcitabine. We evaluated the safety and biological activity of the combination of dasatinib and gemcitabine in patients with advanced solid tumors. Experimental Design In a phase 1 study (3 + 3 design), patients received daily dasatinib with weekly gemcitabine on days 1, 8 and 15 of a 28-day cycle (except cycle 1 which was 8 weeks). Dose escalation began with dasatinib 70 mg orally (PO) daily and gemcitabine 800 mg/m(2) intravenously (IV) weekly. Results Forty-seven patients (15 men; median age = 55 years; median number of prior systemic treatments = 4) were enrolled. Dose-limiting toxicities were grade 3 fatigue and dehydration, with the maximum tolerated dose being dasatinib 100 mg PO qd and gemcitabine 600 mg/m(2) IV weekly. The most common grade 3-4 toxicities were anemia (21.5 %), thrombocytopenia (26.2 %), leukopenia (26.2 %), and pleural effusion (10.7 %). Six of 47 patients attained stable disease (SD) a parts per thousand yenaEuro parts per thousand 6 months or partial response including 2 of 8 patients with pancreatic cancer (SD a parts per thousand yenaEuro parts per thousand 6 months; both gemcitabine-refractory), 2 of 3 patients with thymoma (SD for 9.8 and 15 months), 1 of 1 patient with anal squamous cancer (SD 15 months) and 1 of 5 patients with inflammatory breast cancer. No significant changes in circulating tumor cells or interleukin-8 levels were observed. Conclusions The combination was well tolerated at doses of dasatinib 100 mg PO daily and gemcitabine 600 mg/m(2) IV weekly. SD a parts per thousand yenaEuro parts per thousand 6 months/ PR was observed in gemcitabine-refractory pancreatic cancer, thymoma, anal cancer and inflammatory breast cancer.

• 出版日期2013-8