Delta Opioid Receptor and Its Peptide: A Receptor-Ligand Neuroprotection

作者：Acosta Sandra; Tajiri Naoki; Pabon Mibel; Kaneko Yuji^*; Borlongan Cesar V

来源：International Journal of Molecular Sciences, 2013, 14(9): 17410-17419.

DOI：10.3390/ijms140917410

• stroke
• delta opioid receptors
• neuroprotection
• DADLE
• neuronal death

In pursuit of neurological therapies, the opioid system, specifically delta opioid receptors and delta opioid peptides, demonstrates promising therapeutic potential for stroke, Parkinson's disease, and other degenerative neurological conditions. Recent studies offer strong evidence in support of the therapeutic use of delta opioid receptors, and provide insights into the underlying mechanisms of action. Delta opioid receptors have been shown to confer protective effects by mediating ionic homeostasis and activating endogenous neuroprotective pathways. Additionally, delta opioid agonists such as (D-Ala 2, D-Leu 5) enkephalin (DADLE) have been shown to decrease apoptosis and promote neuronal survival. In its entirety, the delta opioid system represents a promising target for neural therapies.

• 出版日期2013-9