LKB1 loss of function studied in vivo

作者：Shorning Boris Y^*; Clarke Alan R

来源：FEBS LETTERS, 2011, 585(7): 958-966.

DOI：10.1016/j.febslet.2011.01.019

• LKB1
• Animal model
• In vivo

Recent developments have placed the serine/threonine kinase LKB1 on the crossroads linking energy metabolism, cell structure and cancer progression and that its deletion can affect tumorigenesis, metastasis, cell adhesion and polarity. LKB1 can regulate a host of different functions which all have potential to impact upon the initiation and progression of neoplastic disease. To understand the phenotypic consequences of LKB1 loss in a range of different settings, a number of animal models of loss of function have been generated and analyzed. In this review we summarize recent data generated from a range of these models, which reveal clear tissue specific differences in LKB1 function in vivo and in the consequences of its loss.

• 出版日期2011-4-6