Anti-inflammatory Principles from Cordyceps sinensis

作者：Yang Mei Lin; Kuo Ping Chung; Hwang Tsong Long; Wu Tian Shung^*

来源：Journal of Natural Products, 2011, 74(9): 1996-2000.

DOI：10.1021/np100902f

In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has resulted in the identification of 50 compounds, including five constituents, cordysinins A-E (1-5), reported from a natural source for the first time. In addition, compounds were examined for their anti-inflammatory activity. 1-(5-Hydroxymethyl-2-furyl)-beta-carboline displayed the most significant inhibition of superoxide anion generation and elastase release with IC(50) values of 0.45 +/- 0.15 and 1.68 +/- 0.32 mu M, respectively.

• 出版日期2011-9
• 单位中国医科大学; 长春大学