科研之友
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摘要
Upon incorporation of a noncovalent ion pair interaction, a new chiral ferrocenyl bisphosphorus ligand t-Bu-Wudaphos was developed. t-Bu-Wudaphos can be easily synthesized with very high diastereo-selectivity as a highly air stable solid. The new ligand exhibited excellent reactivities and enantioselectivities in the asymmetric hydrogenation of alpha-methylene-gamma-keto-carboxylic acids via an ion pair noncovalent interaction (up to >99% conversion, >99% ee).
