Association study of HLA-B alleles with idiopathic male infertility in Han population of China

作者：Zhou Dang xia^*; Zhang Jing; Wang Hai xu; Wang Xiao fang; Tian Zhao; Zhao Wen bao; Han Shui ping; Zhang Jian; Huo Yong wei; Tian Hong

来源：Journal of Assisted Reproduction and Genetics, 2011, 28(10): 979-985.

DOI：10.1007/s10815-011-9622-9

• Human leukocyte antigen (HLA)-B
• Polymerase chain reaction-sequence-based typing (PCR-SBT)
• Idiopathic male infertility

Purpose To investigate the distributions of HLA-B alleles and estimate their associations with idiopathic male infertility in Chinese Han population.
Methods Polymerase chain reaction-sequence-based typing (PCR-SBT) method was used for DNA typing at HLA-B locus in 109 patients with idiopathic male infertility and 152 healthy controls in male Han population of Shaanxi Province, situated in northwestern China.
Results In total, we detected 45 HLA-B alleles in idiopathic infertile patients, 48 HLA-B alleles in control subjects. However, no significant differences of these allelic frequencies were found between the infertile patients and the controls.
Conclusion HLA-B gene was unlikely a major risk factor of idiopathic male infertility in this sample population. As different populations have different HLA polymorphisms, investigation of the relationship of other HLA genes and idiopathic male infertility with larger sample size, is warranted in the future.

• 出版日期2011-9
• 单位陕西省血液中心; 西安交通大学