Differential diagnosis of membranous nephropathy with autoantibodies to phospholipase A2 receptor 1

作者：Schlumberger Wolfgang^*; Hornig Nora; Lange Sascha; Probst Christian; Komorowski Lars; Fechner Kai; Daehnrich Cornelia; Stoecker Winfried

来源：Autoimmunity Reviews, 2014, 13(2): 108-113.

DOI：10.1016/j.autrev.2013.09.005

• Membranous nephropathy
• Nephrotic syndrome
• Phospholipase A2 receptor 1
• Autoantibodies
• Indirect immunofluorescence
• ELISA

Membranous nephropathy (MN) accounts for most cases of the nephrotic syndrome in adults. Recently, studies on the underlying pathomechanisms led to the identification of the podocyte M-type receptor for secretory phospholipase A2 (PLA(2)R1) as a target antigen of circulating autoantibodies. Autoantibodies to PLA(2)R1 may not only play a role in the development of primary MN, but also serve as a marker for diagnosis, disease activity and therapy monitoring. Antibody detection is crucial to discriminate between patients with primary MN and those with a secondary form of the disease, as both forms require different diagnostic approaches and treatment strategies. Standardized test systems based on recombinant PLA(2)R1 allow for the sensitive and specific analysis of anti-PLA(2)R1 autoantibodies. Further research into pathogenic mechanisms and other disease markers can pave the way for improved patient care.

• 出版日期2014-2