An iron(III) 18-metallacrown-6 complex: synthesis, crystal structure, and bioactivity

作者：Jin, Chengzhi; Yang, Ye^*; Jin, Longfei; Wu, Lamei; Zhang, Jiang

来源：Journal of Coordination Chemistry, 2011, 64(23): 4098-4107.

DOI：10.1080/00958972.2011.636039

• Metallacrown
• Iron complex
• Crystal structure
• Antimicrobial activity

A macrocyclic hexanuclear iron(III) 18-metallacrown-6 complex, [Fe-6(C9H6BrN2O3)(6) (CH3OH)(4)(H2O)(2)]center dot 7CH(3)OH center dot 4H(2)O, has been prepared using a trianionic pentadentate ligand N-acetyl-5-bromosalicylhydrazidate, abshz(3-), and characterized by X-ray diffraction. The crystal structure contains a neutral 18-membered metallacrown ring consisting of six Fe(III) and six abshz(3-) ligands. The 18-membered metallacrown ring is formed by combination of six structural moieties, [Fe(III)-N-N]. Due to meridional coordination of ligand to Fe3+, the ligand enforces the stereochemistry of the Fe3+ ions as a propeller configuration with alternating Delta/Lambda forms. Methanol and water are linked with Fe1, Fe1A, Fe, 3 and Fe3A. The ratios of methanol to water are 0.76 : 0.24 for Fe1 and Fe1A, and 0.30 : 0.70 for Fe3 and Fe3A, which results in four component crystals of metallacrown rings with ratio of 0.168 : 0.072 : 0.532 : 0.228. Antibacterial screening data showed that the iron metallacrown has moderate antimicrobial activity against Bacillus subtilis.

• 出版日期2011
• 单位海南大学; 中南民族大学