Antifungal Saponins from Paris polyphylla Smith

作者:Deng Dawei*; Lauren Denis R; Cooney Janine M; Jensen Dwayne J; Wurms Kirstin V; Upritchard Jenine E; Cannon Richard D; Wang Ming Zhong; Li Ming Zhang
来源:Planta Medica, 2008, 74(11): 1397-1402.
DOI:10.1055/s-2008-1081345

摘要

Three steroidal saponins, including one new and two known compounds, were isolated from the rhizomes of Paris polyphylla Smith. One- and two-dimensional NMR, LC-MS, and interpretation of hydrolytic cleavage experiments led to the identification of the structure of the new saponin as (25R)-spirost-5-ene-3 beta,17 alpha-diol (pennogenin) 3-O-{O-alpha-L-rhamnopyranosyl-(1 -> 2)-O-[O-beta-xylopyranosyl-(1 -> 5)-alpha-L-arabinofuranosyl-(1 -> 4)]-beta-D-glucopyranoside}. The isolated saponins were evaluated for their antifungal activity against Cladosporium cladosporioides and Candida species and showed comparable activity to chemicals used in some commercial products.

  • 出版日期2008-9