A Decrease in the Percentage of CD3(+) Cells Is Correlated With Clinical Improvement During Plasmapheresis in Patients With Myasthenia Gravis

作者：Chien Pei Ju; Yeh Jiann Horng; Shih Chwen Ming; Hsueh Yu Mei; Chen Mei Chieh; Chiu Hou Chang^*

来源：Artificial Organs, 2013, 37(2): 211-216.

DOI：10.1111/j.1525-1594.2012.01531.x

• Myasthenia gravis
• Plasmapheresis
• Plasma exchange
• Lymphocyte subsets
• Thymectomy

Plasmapheresis not only removes circulating antibodies but also modulates cellular immunity, including lymphocyte subsets. To investigate the effect of double-filtration plasmapheresis (DFPP) on the ratio of lymphocyte subsets in patients with myasthenia gravis (MG), we examined the percentages of B-cells, T-cells, T helper (Th) cells, T suppressor (Ts) cells, natural killer (NK) cells, NKT cells, and Th/Ts ratio before and after a single DFPP session and after a course of DFPP. A total of 26 patients were recruited; their peripheral blood lymphocyte subsets were assayed using flow cytometry. After a single session of DFPP treatment, the percentages of T-cells (P=0.0200), Th cells (P=0.0178), and the Th/Ts ratio (P=0.0309) decreased significantly, whereas the percentage of NK cells (P=0.0007) increased significantly. More importantly, after one course of DFPP treatment, the reduced clinical quantitative MG (QMG) score was correlated with the decrease of the percentage of T-cells (r=0.5005, P=0.0092). Fourteen thymectomized MG patients had decreased percentages of T-cells (P=0.0304) and Th cells (P=0.0444), whereas they had increased NK cells (P=0.0197) after a single DFPP session. Here, transiently decreased percentages of T-cells after the full DFPP course could enhance the effectiveness of plasmapheresis for MG patients.

• 出版日期2013-2
• 单位河北医科大学