Genetic Deficiency of Plasma Lipoprotein-Associated Phospholipase A(2) (PLA2G7 V297F Null Mutation) and Risk of Alzheimer's Disease in Japan

作者：Koshy Beena; Miyashita Akinori; St Jean Pamela; Stirnadel Heide; Kaise Toshihiko; Rubio Justin P; Mooser Vincent; Kuwano Ryozo; Irizarry Michael C^*

来源：Journal of Alzheimer's Disease, 2010, 21(3): 775-780.

DOI：10.3233/JAD-2010-100513

• Alzheimer's disease
• apolipoprotein E
• genetic association study
• lipoprotein-associated phospholipase A2
• Mendelian randomization

High plasma lipoprotein phospholipase A(2) activity (Lp-PLA(2)) is reported to be a risk factor for dementia. A loss of function polymorphism in the Lp-PLA(2) gene - PLA2G7 V279F - is found almost exclusively in Asians. In 1,952 subjects with late-onset AD and 2,079 non-demented controls recruited from Japan, the PLA2G7 null allele was not associated with risk or age at onset of AD: logistic regression OR 0.98 (95% CI 0.86-1.12, p = 0.81) per additional null allele, adjusted for age/age at onset, gender, and APOE epsilon 4. Genetic deficiency of Lp-PLA(2) activity is not associated with a reduced risk of AD in the Japanese population.

• 出版日期2010